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RSCN Newsletter 2025/2 highlights how Reference Sites across Europe are translating innovation into real-world impact for healthy ageing and integrated care. From Barcelona hosting COMFORTage’s General Assembly and joint Ageing Deal event, to Campania’s leadership in the RADAR stakeholder meeting on antimicrobial resistance, this issue showcases collaboration between research, healthcare, policy, and communities. Stories from the eGEA Living Lab, the piano donation to Federico II Pediatric Surgery, and the Age-IT national event further illustrate how person-centred, interdisciplinary approaches are shaping resilient health systems for all generations.